Normal and promoted gi absorption of water-soluble substances II: Absorption of vitamin b12 from ligated stomach and intact intestine of the rat

✍ Scribed by W. W. Davis; C. J. Kreutler

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 476 KB
• Volume: 60
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600601112

✦ Synopsis

I J Both normal and promoted absorption of vitamin Blz in the doubly ligated stomach and the intact GI tract of the rat were investigated using 67Co-labeled cyanocobalamin. Very little absorption of vitamin Bl2 occurs normally from the ligated stomach of the rat. Much more absorption is seen from the intact intestine. Both gastric and intestinal absorption are markedly increased by addition of a nonionic surface-active agent, polyoxyethylene-212oleyl ether, to the aqueous solution of the vitamin. The effect of ad libitum feeding upon either normal or promoted absorption is minor. At high vitamin BIZ levels, somewhat more normal absorption occurs in fasted than in fed animals. The results reported here are interpreted to be similar to the effects of surfaceactive absorption promoters on the absorption of other watersoluble substances.