NORMAL AND MALIGNANT BREAST TISSUE IS A TARGET ORGAN FOR 1, 25-(OH)2 VITAMIN D3
β Scribed by J. A. EISMAN; I. MACINTYRE; T. J. MARTIN; R. J. FRAMPTON; R.J.B. KING
- Book ID
- 114717482
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 329 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0300-0664
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The seco-steroid hormone 1a,25(OH) 2 -vitamin D 3 (1,25-D 3 ) is known to generate biological responses via both genomic and non-genomic rapid signal transduction pathways. The calcium regulated annexin II/p11 heterotetramer (AII 2 /p11 2 ] was proposed by Baran and co-authors to be the membrane rec
## Abstract 1Ξ±,25βDihydroxyvitamin D~3~ [1Ξ±,25(OH)~2~D~3~], the hormonally active form of vitamin D~3~, has been shown to be a potent negative growth regulator of breast cancer cells both in vitro and in vivo. 1Ξ±,25(OH)~2~D~3~ acts through two different mechanisms. In addition to regulating gene tr