Norlignans from Sequoia sempervirens

✍ Scribed by Yu-Mei Zhang; Ning-Hua Tan; Ya-Bin Yang; Yang Lu; Peng Cao; Yun-Shan Wu

• Book ID: 101769396
• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 114 KB
• Volume: 2
• Category: Article
• ISSN: 1612-1872
• DOI: 10.1002/cbdv.200590030

✦ Synopsis

Six new norlignans, named sequosempervirins B ± G (1 ± 6), together with three known norlignans, agatharesinol (7), agatharesinol acetonide (8), and sugiresinol (9), were isolated from the branches and leaves of Sequoia sempervirens. Their structures were determined mainly by high-resolution mass spectroscopy (HR-MS), and various 1D-and 2D-NMR methods, as well as, in the case of 1, by means of X-ray diffraction. Compound 8 showed anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC 50 27.1 mm). The acetone extract of S. sempervirens was found to be antifungal towards Candida glabrata (IC 50 15.98 mg/ ml), and both the acetone and MeOH extracts inhibited the proteolytic activity of cathepsin B (IC 50 4.58 and 5.49 mg/ml, resp.).