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Norepinephrine release is reduced in cardiac tissue of Type 2 diabetic patients

✍ Scribed by C. Burgdorf,D. Richardt,T. Kurz,S. Adler,A. Nötzold,E. G. Kraatz…


Book ID
113017708
Publisher
Springer
Year
2003
Tongue
English
Weight
118 KB
Volume
46
Category
Article
ISSN
0012-186X

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## Abstract Poly(ADP‐ribose)polymerase (PARP‐1), a nuclear enzyme activated by DNA strand breaks, is involved in DNA repair, aging, inflammation, and neoplastic transformation. In diabetes, reactive oxygen and nitrogen species occurring in response to hyperglycemia cause DNA damages and PARP‐1 acti