Primary monolayer cultures of adult rat hepatocytes were used to study the temporal interaction of epidermal growth factor (EGF) and insulin in their stimulation of DNA synthesis. The hepatocytes were cultured both under defined conditions and with serum. EGF and insulin interacted synergistically.
Norepinephrine and epidermal growth factor: Dynamics of their interaction in the stimulation of hepatocyte DNA synthesis
โ Scribed by Jennifer L. Cruise; George Michalopoulos
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 588 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Previous data obtained in vivo and in vitro suggest that both prostaglandins (PGs) and catecholamines may have a role in promoting hepatocyte proliferation, and PGE~2~ and PGFF~2ฮฑ~ have also been implicated as mediators of the mitogenic actions of epidermal growth factor (EGF) (and tran
## Abstract The effect of hepatocyte growth factor/scatter factor (HGF/SF) on the proliferation of human skin fibroblasts was examined. At concentrations above 1.0 ng/ml, both native and recombinant human HGF/SF stimulated the DNA synthesis determined by [^3^H]thymidine incorporation, which was com
We have reported that infusion of recombinant human hepatocyte growth factor (rhHGF) stimulates liver regeneration after hepatectomy in cirrhotic rats and increases the level of serum lipids and secretion of very-low density lipoprotein (VLDL). Studies were now performed to determine whether rhHGF d