NORE1A, a homologue of RASSF1A tumour suppressor gene is inactivated in human cancers
โ Scribed by Hesson, Luke; Dallol, Ashraf; Minna, John D; Maher, Eamonn R; Latif, Farida
- Book ID
- 110067312
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 327 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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## Abstract The putative tumor suppressor NORE1A (RASSF5) is a member of the Ras association domain family and is commonly inactivated in human cancer. The closely related gene family member and functional collaborator __RASSF1A__ is a __bona fide__ tumor suppressor and is frequently involved in ne
## Abstract Common fragile sites (CFS) are large, genomically unstable regions, which are hotโspots for deletions and other alterations, especially in cancer cells. Several have been shown to contain genes that span large genomic regions, such as __FHIT__ (1.5 Mb), __WWOX__ (1.0 Mb), __GRID2__ (1.3