## Abstract We have reported that nordihydroguaiaretic acid (NDGA) inhibits the tyrosine kinase activities of the IGFโ1 receptor (IGFโ1R) and the HER2 receptor in breast cancer cells. Herein, we studied the effects of NDGA on the growth of estrogen receptor (ER) positive MCFโ7 cells engineered to o
โฆ LIBER โฆ
Nordihydroguaiaretic Acid (NDGA) Inhibits the IGF-1 and c-erbB2/HER2/neu Receptors and Suppresses Growth in Breast Cancer Cells
โ Scribed by Jack F. Youngren; Karissa Gable; Cristina Penaranda; Betty A. Maddux; Marianna Zavodovskaya; Margaret Lobo; Michael Campbell; John Kerner; Ira D. Goldfine
- Publisher
- Springer US
- Year
- 2005
- Tongue
- English
- Weight
- 330 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0167-6806
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The responsiveness of estrogen receptor (ER)-positive breast cancer to endocrine therapy is frequently reduced in cells over-expressing c-erbB-2. Stimulation of ER suppresses c-erbB-2, indicating that estrogen controls the activity of c-erbB-2. Heregulin (HRG) has been described to bind to c-erbB-3/