𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Norcantharidin Analogues: Synthesis, Anticancer Activity and Protein Phosphatase 1 and 2A Inhibition

✍ Scribed by Timothy A. Hill; Scott G. Stewart; Christopher P. Gordon; Stephen P. Ackland; Jayne Gilbert; Benjamin Sauer; Jennette A. Sakoff; Adam McCluskey

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
440 KB
Volume
3
Category
Article
ISSN
1860-7179

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Total Synthesis and Biological Evaluatio
Total Synthesis and Biological Evaluation of the Protein Phosphatase 2A Inhibitor Cytostatin and Analogues
✍ Laurent Bialy; Herbert Waldmann 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 481 KB 👁 2 views

## Abstract The total synthesis of the natural product cytostatin is described which inhibits protein phosphatase 2A. Cytostatin has anti‐metastatic properties and induces apoptosis. On the basis of this synthesis the relative and absolute configuration of cytostatin could be assigned. Key structur

Apoptosis of human neutrophils induced b
Apoptosis of human neutrophils induced by protein phosphatase 1/2A inhibition is caspase-independent and serine protease-dependent
✍ Hae-Young Park; Min-Gyu Song; Jun-Sik Lee; Ja-Woong Kim; Jun-O Jin; Joo-In Park; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 639 KB

## Abstract Protein phosphatase (PP) activity is associated with the regulation of apoptosis in neutrophils. However, the underlying regulatory mechanism(s) in apoptosis remain unclear. The type of cell death induced by okadaic acid (OA), the inhibitor of PP1 and PP2A, is characterized by apoptotic