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Noonan syndrome, moyamoya-like vascular changes, and antiphospholipid syndrome

✍ Scribed by Yushiro Yamashita; Akira Kusaga; Yasutoshi Koga; Shin-ichiro Nagamitsu; Toyojiro Matsuishi

Book ID
116824644
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
117 KB
Volume
31
Category
Article
ISSN
0887-8994

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Noonan syndrome (NS) is among the most common nonchromosomal disorders affecting development and growth. NS is genetically heterogeneous, being caused by germline mutations affecting various genes implicated in the RAS signaling network. This network transduces extracellular signals into intracellul