Nontoxic Membrane-Active Antimicrobial Arylamide Oligomers

✍ Scribed by Dahui Liu; Sungwook Choi; Bin Chen; Robert J. Doerksen; Dylan J. Clements; Jeffrey D. Winkler; Michael L. Klein; William F. DeGrado

• Book ID: 101560197
• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 178 KB
• Volume: 43
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200352791

✦ Synopsis

Non-natural polymers can adopt specific secondary and tertiary structures that resemble those of naturally occurring biopolymers. [1][2][3][4] As a result of their stability towards enzymatic degradation and their virtually unlimited diversity, nonnatural polymers and oligomers are excellent candidates for therapeutic biomimetics. We previously designed a series of easily synthesized aryl amide oligomers [5] that mimic the properties of membrane-interactive antimicrobial peptides such as the magainins and cecropins. Although these oligomers are highly active, they have significant toxicities toward human cells, as assessed from the hemolytic activities of the compounds. Herein, we describe the fine-tuning of the