Nonsteroidal antiinflammatory drugs and the lupus anticoagulant

✍ Scribed by Jeffrey R. Wohlgethan; Howard R. Smith

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 213 KB
• Volume: 33
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780330725

✦ Synopsis

Table 1. Laboratory findings in patient I . who was receiving continuous ambulatory peritoneal dialysis, after treatment with a single dose of oral methotrexate followed by leucovorin rescue. Serum MTX WBC, level. Hgb. x 10'/mm' Platelets. Date Drug pmolesniter gm/dl (% segments) x IO'lmm' 3/2/89 3/6/89t 3/8/89 3/9/89$ 31 I0/89+ 311 4/89 3/16/89 3120189 2.5 mg MTX -0.12 10.7 9.2 (81) 323 270 75 mg leucovorin 0.09 11.0 75 mg leucovorin 0.13 ND 1.8 (61) ND 75 mg leucovorin 0.10 10.0 0.8 (15) I50 75 mg leucovorin 0.02 7.0 0.5 (24) 99 -ND 6. I 3.1 (30) 35 co.01 9.0 10.0 (27) 71 2.0 (SO) * Serum methotrexate (MTX) levels were determined by fluorescence polarization on a TDX, using Abbott reagents (Abbott Laboratories. North Chicago. IL). Hgb = hemoglobin; WBC = white blood cells; ND = not determined. t Date of hospital admission. $ Charcoal hemoperfusion was performed. leucovorin or hemoperfusion. She was continued on her regimen of hemodialysis 3 times a week, with antibiotic use and standard isolation techniques. Her PM improved and