Nonsteroidal antiinflammatory drug therapy in rheumatoid arthritis patients. Lack of association between clinical improvement and effects on sleep

✍ Scribed by P. Lavie; M. Nahir; M. Lorber; Y. Scharf

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 496 KB
• Volume: 34
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780340605

✦ Synopsis

Thirteen patients with rheumatoid arthritis (mean & SD age 55.8 f 10.5 years) received 20 mg of tenoxicam daily for 90 days following a 3-7-day "washout" period and 4 days of placebo treatment. Clinical evaluations were conducted at the end of the washout period and at monthly intervals thereafter. All-night polysomnography was performed in a sleep laboratory during the last 2 days of placebo treatment and on days 13, 14, 89, and 90 of tenoxicam treatment. Although there was improvement in the patients' clinical condition, there were no treatment-related changes in any of the sleep parameters. Eight of the 13 patients, however, were found to have primary sleep disorders. Four had periodic leg movements during sleep, 3 had sleep apneas, and 1 had a combination of both disorders. The implications of these findings in the treatment of sleep disorders in patients with rheumatoid arthritis are discussed.

The association of chronic arthritic pain with subjective complaints of sleep disturbances and sleep abnormalities is well documented (1-4). These include disturbances in the continuity of sleep, as well as in the qualitative aspects of electroencephalographic (EEG)