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Nonsteroidal anti-inflammatory drugs and coma: A case report of fenoprofen overdose

✍ Scribed by Joan M Kolodzik; Mark A Eilers; Mark G Angelos

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
337 KB
Volume
19
Category
Article
ISSN
1097-6760

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✦ Synopsis

We present the case of a 17-year-old girl who ingested 24 to 36 g fenoprofen as a suicidal gesture. She presented with coma, hypotension, metabolic acidosis, and respiratory depression within four hours of ingestion. The most common adverse effects of the nonsteroidal anti-inflammatory drugs occur in both therapeutic and toxic doses and include gastrointestinal upset, blood dyscrasias, and analgesic nephropathy. The propionic acid derivatives of nonsteroidal anti-inflammatory drugs, including fenoprofen and ibuprofen, are rarely associated with severe toxic effects. This is the first report of pure fenoprofen overdose presenting as coma and metabolic acidosis.

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