Nonsteady-state simulation of extended cultures in tower loop reactors

✍ Scribed by R. Luttmann; M. Thoma; H. Buchholz; K. Schügerl

• Publisher: Elsevier Science
• Year: 1982
• Tongue: English
• Weight: 968 KB
• Volume: 37
• Category: Article
• ISSN: 0009-2509
• DOI: 10.1016/0009-2509(82)80049-3

✦ Synopsis

Hansmulo potymorpha was cultivated in extended culture in an air Lit tower loop reactor wifh the substrates enthanol and glucose, respectively. The spa&l and time variations of process variables were simulated by a hybrid computer by means of a distributed parameter (dispersion) model, taking into account the spa&l variations of pressure, volumetricmass transfer coefficient, dissolvedoxygenconcentration,oxygen gas phasemole fractionandgas velocity. The volumetric mass transfer coefficient at the gas entrance, kLa desciibed by a coalescence factor, Ksr, ", its variation near the gas distributor, and the oxygen saturation constant, K,,, were identified by quasi-steady-state methods.

The kinetic parameters, maximum specific growth rate, -, and oxygen yield coefficient, Yx7,.,, were identified during nonstationary simulation. The distributed parameter cultivation processes were simulated in a z (dimensionless longitudinal distancebt (cultivation time)-space. The agreement between calculated and measured process variables is excellent.