Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells
โ Scribed by Seiki, Motoharu (author);Eddy, Roger (author);Shows, Thomas B. (author);Yoshida, Mitsuaki (author)
- Book ID
- 109735780
- Publisher
- Nature Publishing Group
- Year
- 1984
- Tongue
- English
- Weight
- 473 KB
- Volume
- 309
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/309640a0
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๐ SIMILAR VOLUMES
## Introduction Human T-cell leukemia virus (HTLV) was isolated from a cutaneous T-cell lymphoma patient by Gallo and his colleagues (Poiesz et al., 1980) and adult T-cell leukemia virus (ATLV) was isolated from patients with adult T-cell leukemia (ATL) in Japan (Yoshida et al., 1982). Originally,
An HTLV-I-seronegative case of adult T-cell leukemia (ATL) carrying the HTLV-I genome is reported. Screening serological tests were negative and Western blot analysis revealed only a faint band for HTLV-I p24. Polymerase chain reaction (PCR) disclosed the presence of HTLV-I gag, PO/, env, pX, and LT