Nonspecific influx of cytotoxic T cells into influenza virus-infected lungs of mice
β Scribed by Zhang Yong-He; Mak Nai-Ki
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 322 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0360-3997
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Swiss albino male mice were administered two doses (1 and 2 HA units) of influenza A2 Hong Kong/68 virus IP. The incidence of chromosomal anomalies in spermatocytes was analysed at various times post infection and was found to be significantly higher than in controls, indicating that the influenza v
Anti-viral cytotoxic T cells (Tc) recognize virus only in conjunction with class I MHC molecules in man and mouse (Zinkernagel and Doherty 1979). Antibodies directed to the target cell H-2 molecule inhibit T-cell-mediated cytotoxicity, while no inhibition is observed when anti-H-2 binds to the Tc an