Nonspecific augmentation of lymph node T cells and I-E-independent selective deletion of VβbTl4+ T cells by Mtv-2 in the DDD mouse
✍ Scribed by Hideki Nakano; Takayuki Yoshimoto; Terutaka Kakiuchi; Akio Matsuzawa
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 578 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
✦ Synopsis
Nonspecific augmentation of lymph node T cells and I-E-independent selective deletion of Vp14+ T cells by Mtv-2 in the DDD mouse*
DDD/1 (DDD) mice were characterized by marked paucity of Tcells in lymph nodes (LN). In DDD-Mtv-2IMtv-2 (DDD-Mtv-2) congenics, Tcells were 4-to 18-fold increased depending on ages but B cells doubled at the most. Thymus weight also increased. In DDDfDDD-Mtv-2, DDD neonatally infected with Mtv-2-derived exogenous MMTV (MMTV-2), neither LN cells nor thymus weight increased. The Vp5+ and VpS+ Tcell contents in LN were practically the same among three strains. The Mtv-2-induced expansion of LN Tcells was polyclonal and appeared indigenous to DDD mice. Both Mfv-2 and MMTV-2 induced progressive age-dependent deletion of Vg14+CD4+ LN cells. Mtv-2 but not MMTV-2 caused deletion of Vp14+CDSf LN cells and mature Vp14+CD4+ thymocytes.Thus, Mtv-2-and MMTV-2-induced Vp14+ Tcell deletion may reflect intrathymic and peripheral elimination, respectively. The absence of I-E gene expression in DDD indicates that Vp14+ T cell deletion advances independently of I-E molecules in this experimental system.