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Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse

โœ Scribed by Wajnrajch, Michael P.; Gertner, Joseph M.; Harbison, Madeleine D.; Chua, Streamson C.; Leibel, Rudolph L.


Book ID
109914963
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
380 KB
Volume
12
Category
Article
ISSN
1061-4036

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The little (lit) mutation cosegregates w
โœ Streamson C. Chua; Karen Hennessey; Phillip Zeitler; Rudolph L. Leibel ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 529 KB

The little (lit) autosomal recessive mutation in the mouse causes dwarfism due to isolated growth hormone deficiency. The in vitro physiology of pituitary growth hormone release in lit~lit animals suggests that an abnormality in the growth hormone releasing factor (GRF) receptor (Ghrfr) is a very li