Nonresponse to hepatitis B vaccines and the kinetics of anti-HBs production

✍ Scribed by Zuckerman, Jane N.

• Book ID: 102646911
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 714 KB
• Volume: 50
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/(sici)1096-9071(199612)50:4<283::aid-jmv1>3.0.co;2-4

✦ Synopsis

No empirical data are available for the anti-HBs titre required for protection against infection with the hepatitis B virus (HBV), but nonresponders to hepatitis B vaccines remain susceptible to infection. There may be an unexplained qualitative difference between hyporesponders and true nonresponders, but there is a clear association with HLA haplotypes. There is no evidence for silent infection with HBV in nonresponders.