Nonreceptor Tyrosine Phosphatases in Cellular Signaling: Regulation of Mitogen-Activated Protein Kinases
β Scribed by Zhan, Xiao-Li; Wishart, Matthew J.; Guan, Kun-Liang
- Book ID
- 127253776
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 286 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0009-2665
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π SIMILAR VOLUMES
The regulation of tyrosine phosphorylation represents a key mechanism governing cell proliferation. In fibroblasts, inputs from both growth factor and extracellular matrix receptors are required for cell division. Triggering such receptors induces a wave of tyrosine phosphorylation on key signaling
Intracellular signaling proteins are very often regulated by site-specific phosphorylation. For example, growth factor receptors in eukaryotic cells contain intrinsic tyrosine kinase activity and use inter- and intra-molecular interactions to recruit and orient potential protein substrates for phosp