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Nonpeptide angiotensin II receptor antagonists

โœ Scribed by Pieter B.M.W.M. Timmermans; Pancras C. Wong; Andrew T. Chiu; William F. Herblin


Book ID
119112677
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
940 KB
Volume
12
Category
Article
ISSN
0165-6147

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## Abstract A series of Losartan analogues **1โ€12** with different functional groups were synthesized and characterized. In comparison with the previous reports, the synthetic procedures described in this paper have been optimized as follows below: 1) preparation of aromatic amine **15** and **18**