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Nonparametric Comparison of Longitudinal Response Patterns from Paired Samples Using Configural Frequency Analysis

✍ Scribed by Prof. Dr. Alexander Von Eye; Prof. Dr. Dr. Gustav A. Lienert

Book ID: 102759114
Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 538 KB
Volume: 29
Category: Article
ISSN: 0323-3847
DOI: 10.1002/bimj.4710290513

No coin nor oath required. For personal study only.

✦ Synopsis

Nonparametric methods of Configural Frequency Analyaie (CFA) for comparing longitudinal response pattern are d i e c u d . Characteristits of diagonally symmetric frequency dirrtributiona are mapped with hypotheses on the locus of treatment effecta. Teat sfetistica for the a ~l p i e of local dependencies are d i e d . In particular, applications to paired eempl& am considered. A biomedical example is given from research on the effects of Bpssmolytio drugs. Local CFAtesting ie compared with global testing. Alternative atratagiea of teating and the mpective underlying aasumptions are discueaed.

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✍ Prof. Dr. Dr. G. A. Lienert; Prof. Dr. A. Von Eye 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 706 KB

Nonparametric methode of Configural Frequency Analysis (CFA) for the comparison of longitudinal response patterns are d i a c d . In particular, methods of transforming response patterns into profiles that can be analyzed wing CFA are presented. When two independent samples are given, two sample CFA

Saliva and serum samples were collected

Saliva and serum samples were collected from eight healthy volunteers every two hours during a 26-hour period. Melatonin concentrations were measured by radioimmunoassay after chloroform extraction using radioiodinated melatonin as a tracer. Five of the subjects had high serum melatonin levels at night (peak levels higher than 75 pg/ml); in three subjects the highest serum melatonin concentration was 20-40 pg/ml. All subjects had low levels (P <0.001, was obtained for all detectable value pairs (n= 73). The regression and correlation coefficients were almost equal for the peak values of melatonin and during the rising and descending phases of the secretion patterns. However, no significant correlation was found between low daytime salivary and serum concentrations when calculated separately. In the five high-secretors the melatonin levels in saliva reflected reliably the changes in serum, but in the three low-secretors the correlation between salivary and serum melatonin was not significant. The proportion of melatonin found in saliva decreased with increasing serum melatonin levels. Circadian rhythm parameters were estimated by single cosinor analysis. The acrophases did not differ significantly within a subject in the concomitant measurements of serum and salivary melatonin. The measurements of salivary melatonin levels seem valid for studies on melatonin rhythms, but the melatonin concentrations measured in saliva do not always consistently reflect the absolute concentrations in blood.

✍ Maija-Liisa Laakso; Tarja Porkka-Heiskanen; Aino Alila; Dag Stenberg; Gunnar Joh 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 622 KB