✦ LIBER ✦

Nonnatural substrates for polyketide synthases and their associated modifying enzymes

✍ Scribed by Nicola L Pohl

Book ID: 104414700
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 73 KB
Volume: 6
Category: Article
ISSN: 1367-5931
DOI: 10.1016/s1367-5931(02)00360-5

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✦ Synopsis

Polyketides are a large class of structurally diverse, biologically active natural products. Recent experiments add evidence that many of the enzymes involved in the biosynthesis of these natural products are intrinsically tolerant of nonnatural substrates. In addition, an increasing understanding of structure-function relationships in various enzyme-substrate systems is aiding efforts to begin engineering these proteins for even greater synthetic utility.

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