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Nonnatural Amino Acid Synthesis by Using Carbon–Hydrogen Bond Functionalization Methodology

✍ Scribed by Ly Dieu Tran; Prof. Dr. Olafs Daugulis

Book ID
111999968
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
504 KB
Volume
124
Category
Article
ISSN
0044-8249

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📜 SIMILAR VOLUMES

Asymmetric synthesis of α-substituted am
Asymmetric synthesis of α-substituted amino acids and amines by carbon–carbon bond formation in position α to the nitrogen
✍ Kolb, Michael ;Barth, Jacqueline 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 1015 KB

## Abstract The asymmetric synthesis of α‐substituted α‐amino acids and propargylamines is described. As chiral auxiliary we used (__S__)‐(–)‐1‐dimethoxymethyl‐2‐methoxymethylpyrrolidine (SDMP, **1**). Treatment of the amino acids or amines with SDMP **1** afforded the corresponding amidines **C**,