Nonmetastatic thoracic neuroblastomas: A review of 40 cases

✍ Scribed by Rubie, Hervé ;Hartmann, Olivier ;Giron, Alain ;Lemoine, Georges ;Gruner, Max ;Brugieres, Laurence ;Valteau-Couanet, Dominique ;Robert, Alain ;Lemerle, Jean

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 440 KB
• Volume: 19
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950190408

✦ Synopsis

From 1982 to 1987, 40 children with non-metastatic thoracic neuroblastoma were treated with the same therapeutic regimen. According to TNM staging, there were 11 CS I, 19 CS II, and 10 CS III. All patients underwent surgery; 30 had primary surgical excision; in 10 whose tumors were deemed unresectable, surgery was delayed until after a trial of chemotherapy. Operation was completed by several courses of chemotherapy in case of microscopic residual disease or regional lymph node involvement; radiotherapy was delivered in case of gross residual disease. Using this therapeutic approach, EFS is 92% with a median follow-up of 40 months. Severe complications were rare and sequellae appear to be related to the disease, i.e., neurologic consequences of cord compression.