𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Nonlinear pharmacokinetics for the elimination of 5-fluorouracil after intravenous administration in cancer patients

✍ Scribed by B. J. McDermott; H. W. Berg; R. F. Murphy


Publisher
Springer
Year
1982
Tongue
English
Weight
568 KB
Volume
9
Category
Article
ISSN
0344-5704

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Single nucleotide polymorphism in the 5′
✍ Eugenio Marcuello; Albert Altés; Elisabeth del Rio; Angeles César; Anna Menoyo; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 84 KB 👁 1 views

## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has

Investigation of 5-FU disposition after
✍ Yuko Tsukamoto; Yukio Kato; Masako Ura; Ikuo Horii; Tohru Ishikawa; Hideo Ishits 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 274 KB 👁 2 views

## Abstract The nonlinear pharmacokinetics of capecitabine, a triple prodrug of 5‐FU preferentially activated in tumour tissues, was investigated in human cancer xenograft models. A physiologically based pharmacokinetic (PBPK) model integrating the activation process of capecitabine to 5‐FU and 5‐F