✦ LIBER ✦

Nonlinear pharmacokinetics and protein binding of tiaprofenic acid in female Lewis rats

✍ Scribed by Lisa Jo Benincosa; Marilyn E. Morris

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 252 KB
Volume: 82
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600820418

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Evaluation of pharmacokinetics, brain le

Evaluation of pharmacokinetics, brain levels and protein binding of centpropazine in rats

✍ Venkatesh Atul Bhattaram; Jyoti K. Paliwal; Ram C. Gupta 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 108 KB 👁 2 views

Stereoselective pharmacokinetics of ibup

Stereoselective pharmacokinetics of ibuprofen in rats: effect of enantiomer-enantiomer interaction in plasma protein binding

✍ Tomoo Itoh; Jun Maruyama; Yasuyuki Tsuda; Hideo Yamada 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 212 KB 👁 2 views

Stereoselective pharmacokinetics of ibuprofen (IB) enantiomers were studied in rats. Unidirectional conversion from R-ibuprofen (R-IB) to S-ibuprofen (S-IB) was observed following intravenous administration. S-IB concentrations in plasma following racemate administration were simulated according to

Alpha-1-acid glycoprotein directly affec

Alpha-1-acid glycoprotein directly affects the pharmacokinetics and the analgesic effect of methadone in the rat beyond protein binding

✍ Monica Rodriguez; Ignacio Ortega; Itziar Soengas; Nerea Leal; Elena Suarez; Rosa 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 172 KB 👁 1 views

Methadone is a basic drug highly bound to a1-acid glycoprotein (AGP), a plasma protein that increases in several pathological situations. Our aims were to evaluate the processes (pharmacokinetics-PK and/or pharmacodynamics-PD) associated with changes of methadone analgesia under conditions of increa

Comparative pharmacokinetics of coumarin

Comparative pharmacokinetics of coumarin anticoagulants XXX: Relationship between total clearance and serum protein binding of dicumarol in rats

✍ Chh-Ming Lai; Gerhard Levy 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 359 KB

Comparative pharmacokinetics of coumarin

Comparative pharmacokinetics of coumarin anticoagulants XIV: Relationship between protein binding, distribution, and elimination kinetics of warfarin in rats

✍ Avraham Yacobi; Gerhard Levy 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 English ⚖ 466 KB

d e n quantitation of small sulfamethazine peaks impractical. The chloroform wash of the basic aqueous mixture seems to affect this component m a t . Overwashing at this point, however, causes a loss of sulfamethazine. Homogenizing or grinding the tissue prior to extraction tends to improve recover

The nonlinear pharmacokinetics of predni

The nonlinear pharmacokinetics of prednisone and prednisolone. II. Plasma protein binding of prednisone and prednisolone in rabbit and human plasma

✍ Jame S. J. Ferry; John G. Wagner 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 451 KB 👁 2 views

The protein binding characteristics of prednisone and prednisolone were determined in human and rabbit plasma and in a 4.7 per cent human serum albumin (HSA) solution. The influence of plednisolone on prednisone binding in human plasma was also examined. Prednisolone exhibited nonlinear binding and