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Nonlinear model-based estimates of IC50 for studies involving continuous therapeutic dose–response data

✍ Scribed by Robert H. Lyles; Cliff Poindexter; Angelo Evans; Milton Brown; Carlton R. Cooper

Book ID
116350750
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
404 KB
Volume
29
Category
Article
ISSN
1551-7144

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✍ Elzbieta Wyska; Donald E. Mager; Wojciech Krzyzanski 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 257 KB

The basic indirect response models are described by several pharmacodynamic parameters of which IC(50) (drug concentration eliciting 50% of the maximum inhibition) and SC(50) (drug concentration eliciting 50% of the maximum stimulation) are not readily derived from the response versus time or respon