By integration of the second-order fluid pressure over the instantaneous wetted surface, the generalized first-and second-order fluid forces used in nonlinear hydroelastic analysis are obtained. The expressions for coefficients of the generalized first-and second-order hydrodynamic forces in irregular waves are also given. The coefficients of the restoring forces of a mooring system acting on a flexible floating body are presented. The linear and nonlinear three-dimensional hydroelastic equations of motion of a moored floating body in frequency domain are established. These equations include the second-order forces, induced by the rigid body rotations of large amplitudes in high waves, the variation of the instantaneous wetted surface and the coupling of the first order wave potentials. The first-order and second-order principal coordinates of the hydrelastic vibration of a moored floating body are calculated. The frequency characteristics of the principal coordinates are discussed. The numerical results indicate that the rigid resonance and the coupling resonance of a moored floating body can occur in low frequency domain while the flexible resonance can occur in high frequency domain. The hydroelastic responses of a moored box-type barge are also given in this paper. The effects of the second-order forces on the modes are investigated in detail.