Nonlinear dependence in comparative molecular field analysis

✍ Scribed by Ki Hwan Kim

• Book ID: 104639188
• Publisher: Springer Netherlands
• Year: 1993
• Tongue: English
• Weight: 538 KB
• Volume: 7
• Category: Article
• ISSN: 0920-654X
• DOI: 10.1007/bf00141576

✦ Synopsis

The applicability of the comparative molecular field analysis (CoMFA) approach to describe the nonlinear dependence of biological activity on lipophilicity in 3D quantitative structure-activity relationships (QSAR) has been demonstrated. The results indicate that the CoMFA approach is appropriate for describing nonlinear effects in 3D QSAR studies.