Noninvasive Visualization of in Vivo Drug Delivery of Poly( l -glutamic acid) Using Contrast-Enhanced MRI
โ Scribed by Ye, Furong; Ke, Tianyi; Jeong, Eun-Kee; Wang, Xuli; Sun, Yongen; Johnson, Melody; Lu, Zheng-Rong
- Book ID
- 127381673
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 428 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1543-8384
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Poly(L-glutamic acid) (PGA)-cystamine-[gadolinium (Gd)-DO3A] was prepared in high yield with a high Gd-DO3A conjugation efficiency. Approximately 55% of the carboxylic groups in PGA were loaded with Gd-DO3A via cystamine as the spacer. Cystamine can be readily cleaved by endogenous thiols to release