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Noninvasive Prenatal Diagnosis of Fetal Trisomy 18 and Trisomy 13 by Maternal Plasma DNA Sequencing

✍ Scribed by Chen, Eric Z.; Chiu, Rossa W. K.; Sun, Hao; Akolekar, Ranjit; Chan, K. C. Allen; Leung, Tak Y.; Jiang, Peiyong; Zheng, Yama W. L.; Lun, Fiona M. F.; Chan, Lisa Y. S.


Book ID
111922188
Publisher
Public Library of Science
Year
2011
Tongue
English
Weight
212 KB
Volume
6
Category
Article
ISSN
1932-6203

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In a pilot study to establish fetal nucleated red blood cell (NRBC) detection in maternal blood, trisomy 13 was diagnosed by FISH analysis at 11 weeks' gestation. The NRBCs were detected after a single-step ficoll density gradient enrichment. In blood samples taken both before and after CVS, 52 and