✦ LIBER ✦

Noninvasive measurement of the pH inside the gut by using pH-sensitive nitroxides. An in vivo EPR study

✍ Scribed by Bernard Gallez; Karsten Mader; Harold M. Swartz

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 427 KB
Volume: 36
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910360507

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✦ Synopsis

Abstract

The use of pH‐sensitive probes permits the measurement of the proton activity in biological systems by EPR spectroscopy. To illustrate the potential of this technique for in vivo purposes, the authors took advantage of the oral administration of nitroxides to monitor the pH value inside the stomach of mice after administration of different antacidics. The results indicate that EPR can be a valuable tool to characterize the pH in vivo in a continuous and noninvasive way.

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A study was made of the in vivo detectability of a pH-sensitive, imidazolidine spin probe, and the efficacy of low-frequency electron spin resonance (ESR)-based techniques for pH measurement in vitro and in vivo in rats. The techniques used were longitudinally-detected ESR (LODESR) and field-cycled