Noninvasive analysis of aldose reductase activities in rat testis: 3-FDG NMR spectroscopy and imaging

✍ Scribed by Tsutomu Nakada; Ingrid L. Kwee

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 259 KB
• Volume: 29
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910290417

✦ Synopsis

Abstract

Noninvasive investigation of aldose reductase activities in rat testis was performed using 3‐fluoro‐3‐deoxy‐D‐glucose (3‐FDG) and nuclear magnetic resonance (NMR) spectroscopy/imaging. Quantitative determination of testis aldose reductase activities, expressed as the sorbitol index, showed a value similar to that of brain. Sorbitol imaging demonstrated aldose reductase activities in testis to be confined primarily to the central region of this organ. The 3‐FDG ^19^F NMR method appears to have clinical potential in the evaluation of testicular function, especially that of spermatogenesis, noninvasively.