Noninteraction of temazepam and cimetidine
โ Scribed by David J. Greenblatt; Darrell R. Abernethy; Marcia Divoll; Ann Locniskar; Jerold S. Harmatz; Richard I. Shader
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 343 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
Enantiomers of temazepam (TMZ), an anxiolytic drug in clinical use, were resolved and stabilized by the use of aprotic solvents in chiral stationary phase high-performance liquid chromatography (CSP-HPLC). The enantiomers were used to study racemization and heteronucleophilic substitution (alcoholys
Twenty-four healthy volunteers, aged 21-59 years, received single 30 mg oral doses of the benzodiazepine hypnotic temazepam. Levels of intact temazepam were determined in multiple plasma samples drawn during 48 h after dosage. Intact temazepam, its direct glucuronide conjugate, and the conjugate of