Nonenzymatic hydrolysis reactions of adenosine 5′-triphosphate and its related compounds—III: Catalytic aspects of some cobalt(III) complexes in ATP-hydrolysis

✍ Scribed by Shinnichiro Suzuki; Tadayoshi Higashiyama; Akitsugu Nakahara

• Publisher: Elsevier Science
• Year: 1978
• Weight: 717 KB
• Volume: 8
• Category: Article
• ISSN: 0006-3061
• DOI: 10.1016/s0006-3061(00)80162-3

✦ Synopsis

Trichlorodiethylenetriaminecobalt (III), [CoClgdien] , which is provided with three good leaving ligands and, hence, capable of binding ATP in a characteristic mode, accelerated effectively and specifically hydrolysis of ATP to ADP and Pi. A kinetic study of the reaction indicated that the rate of hydrolysis was first order with respect to the concentration of ATP in the presence of an excess of [CoClgdien]. The rate constant was calcnlated to be 1.05 X 10v2 min-' at pH 4.0 (SO"C), corresponding to a catalysis of the hydrolysis of ATP by a factor of 150. The complex possessing one good ions mostly exhibit only poor catalytic activities in aqueous solution [3-53,