Noncovalently Bound Cofactors for Chemical Nucleases

✍ Scribed by Anne Roigk; Hans-Jörg Schneider

• Book ID: 102676653
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 578 KB
• Volume: 2001
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/1099-0690(200101)2001:1<205::aid-ejoc205>3.0.co;2-f

✦ Synopsis

A large range of amino acids, including protected ones, were tested as cofactors in the Eu III -catalyzed hydrolysis of the biocidic bi(nitrophenyl)phosphate (BNPP) and of plasmid DNA. Serine, histidine, and aspartic acidand combinations of thesewere found to be the most effective acids. An azacrown with two attached imidazoles led to more pronounced