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Nonclassical 5-substituted tetrahydroquinazolines as potential inhibitors of thymidylate synthase

✍ Scribed by Aleem Gangjee; Anil Vasudevant; Roy L. Kisliuk

Book ID: 102892824
Publisher: Journal of Heterocyclic Chemistry
Year: 1997
Tongue: English
Weight: 662 KB
Volume: 34
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570340605

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📜 SIMILAR VOLUMES

ChemInform Abstract: Nonclassical 5-Subs

ChemInform Abstract: Nonclassical 5-Substituted Tetrahydroquinazolines as Potential Inhibitors of Thymidylate Synthase.

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Novel 2-Amino-4-oxo-5-arylthio-substitut

Novel 2-Amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as Nonclassical Antifolate Inhibitors of Thymidylate Synthase.

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ChemInform Abstract: 2-Amino-4-oxo-5-sub

ChemInform Abstract: 2-Amino-4-oxo-5-substituted-pyrrolo(2,3-d)pyrimidines as Nonclassical Antifolate Inhibitors of Thymidylate Synthase.

✍ A. GANGJEE; F. MAVANDADI; R. L. KISLIUK; J. J. MCGUIRE; S. F. QUEENER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

The synthesis of novel nonclassical reve

The synthesis of novel nonclassical reversed bridge quinazoline antifolates as inhibitors of thymidylate synthase

✍ Aleem Gangjee; Mohit Kotharé; Roy L. Kisliuk 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 427 KB

## Abstract 2‐Amino‐6‐methyl‐5‐(pyridin‐4‐ylsulfanyl)‐3__H__‐quinazolin‐4‐one (**3**, AG337) a lipophilic thymidylate synthase inhibitor, is currently in clinical trials as an antitumor agent. On the basis of the crystal structure of **3** and the classical inhibitor 10‐propargyl‐5,8‐dideazafolic a

Synthesis of Nonclassical Quinazolinone

Synthesis of Nonclassical Quinazolinone Antifolates as Thymidylate Synthase Inhibitors and Their Antitumor Activity in vitro.

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Synthesis of Classical and Nonclassical

Synthesis of Classical and Nonclassical 2-Amino-4-oxo-6-benzylthieno[2,3-d]pyrimidines as Potential Thymidylate Synthase Inhibitors.

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