Nonclassic measles infections in an immune population exposed to measles during a college bus trip
✍ Scribed by Helfand, Rita F.; Kim, David K.; Gary, Howard E.; Edwards, Gary L.; Bisson, Gregory P.; Papania, Mark J.; Heath, Janet L.; Schaff, Debbie L.; Bellini, William J.; Redd, Stephen C.; Anderson, Larry J.
- Book ID
- 101216551
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 69 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
This study investigated the frequency of mild or asymptomatic measles infections among 44 persons exposed to a student with measles during a 3-day bus trip using two buses. Questionnaires and serum samples were obtained 26-37 days after the trip. All participants had detectable measles-neutralizing antibodies, and none developed classic measles symptoms. Ten persons (23%) were IgM positive for measles, indicating recent infection. Among previously vaccinated IgM-negative persons, those who rode on bus A with the index case-patient had significantly higher microneutralization titers than those on bus B (P = .001), suggesting that some persons on bus A were infected but were IgM negative at the time of the study. Mild or asymptomatic measles infections are probably very common among measles-immune persons exposed to measles cases and may be the most common manifestation of measles during outbreaks in highly immune populations.