Nonaqueous titration of sulfates of quinine and quinidine using barium acetate

✍ Scribed by Sobhi A. Soliman; Hassan Abdine; Nashaat A. Zakhari

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 409 KB
• Volume: 65
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600650327

✦ Synopsis

A nonaqueous titrimetric method is proposed for determining the diastereomeric sulfates of quinine and quinidine. The sulfuric acid content of the alkaloid salts is precipitated, in the form of barium sulfate, with acetous barium acetate solution before the liberated alkaloid is titrated; the necessary calculations are provided. A favorable characteristic of the proposed procedure is the accuracy, speed, and ease of performance. The mean percent recoveries ( p = 0.05) obtained with the proposed method for the sulfates of quinine and quinidine were 98.84 f 1.00 and 99.74 f 1.27, respectively, compared with 100.73 f 1.44 and 100.82 f 1.16, respectively, when the BP 1968 procedure was applied.

Keyphrases 0 Quinine sulfate-nonaqueous titrimetric analysis of base after barium acetate precipitation of sulfate, pure compound and synthetic tablets [7 Quinidine sulfate-nonaqueous titrimetric analysis of base after barium acetate precipitation of sulfate, pure compound and synthetic tablets 0 Titrimetry-analysis, quinine sulfate and quinidine sulfate, pure compound and synthetic tablets Sulfates of nitrogenous bases were determined by several nonaqueous titration methods. The free alkaloid may be extracted in chloroform or carbon tetrachloride from its sulfate salt and then titrated against standard p -toluenesulfonic acid (1). When sulfates of nitrogenous bases were titrated directly against perchloric acid, only one equivalent of the base was titrated (2); the other equivalent, being bound in the form of bisulfate, was not titratable. 40, 173(1951).