## Abstract The loss of dopaminergic neurons in the substantia nigra provokes a plasticity of corticostriatal synapses in Parkinson's disease (PD). The corticostriatal pathway nevertheless makes synapses with neurons bearing D1 dopamine receptors (D1R) and/or D2 dopamine receptors. At the ultrastru
โฆ LIBER โฆ
Nonaminergic striatal neurons convert exogenous l-dopa to dopamine in parkinsonism
โ Scribed by Eldad Melamed; Franz Hefti; Richard J. Wurtman
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 603 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0364-5134
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Early diagnosis of Parkinson's disease (PD) is important for the potential application of neuroprotective therapies. The purpose of this study was to assess the detection of the early changes of PD by either imaging the dopamine transporter (DAT) or uptake of L-3,4-dihydroxyphenylalanine (L-DOPA). A