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Non-viral ex vivo hepatic gene transfer by in situ lipofection of liver and intraperitoneal transplantation of hepatocytes

✍ Scribed by P.N. Rangarajan; P.G. Vatsala; M.S. Ashok; V.K. Srinivas; C.M. Habibullah; G. Padmanaban

Book ID: 117522034
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 637 KB
Volume: 190
Category: Article
ISSN: 0378-1119
DOI: 10.1016/s0378-1119(96)00640-3

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## Abstract ## Background Stability, integrity and retention of the DNA within the targeted tissue is decisive for efficient gene transfer using naked DNA. Pre‐clinical and clinical studies require reproducible transfection rates by preventing rapid degradation of naked DNA in the transduced tissu