✦ LIBER ✦

Non-traditionally derived CTL epitopes: exceptions that prove the rules?

✍ Scribed by Shawn-Marie Mayrand; William R Green

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 168 KB
Volume: 19
Category: Article
ISSN: 0167-5699
DOI: 10.1016/s0167-5699(98)01342-5

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✦ Synopsis

Recent data indicate that cytotoxic T lymphocyte (CTL) epitopes in viral, tumor and model systems are encoded by non-primary open reading frame (ORF) sequences, as well as other non-traditional sources. Here, Shawn-Marie Mayrand and William Green review these findings and discuss whether these non-traditionally derived CTL epitopes influence the shaping of the T-cell repertoire and immune regulation.