Non-T, non-B childhood acute lymphoblastic leukemia. Correlation between cytochemical markers and first complete remission

✍ Scribed by Giuseppe Basso; Carlo Agostini; Maria G. Cocito; Antonio Pezzutto; Roberta Destro; Fabrizia Capuzzo; Maria V. Gazzola; Roberto Raimondi; Luigi Zanesco; Giampietro Semenzato

• Book ID: 101326542
• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 498 KB
• Volume: 54
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19840915)54:6<981::aid-cncr2820540606>3.0.co;2-y

✦ Synopsis

The positivity for four cytochemical reactions, acid phosphatase (AcP), alpha-naphtyl acid acetate esterase (ANAE), beta-glucuronidase (BG), and N-acetyl beta-glucosaminidase (NABG) was correlated to first remission duration in 120 children affected with non-T, non-B acute lymphoblastic leukemia (ALL). The percentages of patients remaining in complete remission at 72 months were always higher for children whose blasts lacked these enzymatic reactions; however, a statistical difference was found only between BG' and BG-ALL. It also appears that more complete enzymatic patterns of leukemic cells are associated with a poorer prognosis. The percentage of patients still in their first remission was 89% for leukemias with no cytochemical markers, 59% when one reaction was present, but less than 39% when two or more enzymes were detected in the blasts. It is noteworthy that the blasts of patients with more severe prognosis demonstrated a simultaneous positivity for AcP-ANAE or BG-NABG cytochemical reactions. The possible usefulness of these cytochemical markers to detect subsets of patients with different prognostic significance among non-T, non-B ALL is discussed.