Non-specific and specific active immunotherapy in a B16 murine melanoma system

✍ Scribed by J. Avent; C. Vervaert; H. F. Seigler

• Book ID: 102924981
• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 526 KB
• Volume: 12
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930120111

✦ Synopsis

Conflicts amongst reports concerning the efficacy of both nonspecific and specific attempts at immunotherapy may be ascribed to different animal models utilizing tumors of different immunogenicity. We have selected the B 16 mouse melanoma model as the example of a spontaneously occurring neoplasm that is histocompatible with the host and does have tunior-associated antigens. Attempts t o alter tumor growth or survival with nonspecific active imrnunotherapy as well as with specific active irnmunotherapy were not successful. Nonspecific active pre-iimnunization failed t o alter tumor take or growth. Specific active immunotherapy both with and without adjuvant did decrease tumor take and prolong host survival. The effects were increasingly documented at lower tumor cell inoculums and became less apparent with increase in the tumor cell challenge.