## Abstract Recent studies have indicated that the brainโderived neurotrophic factor (__BDNF__) gene is involved in the etiology of bipolar disorder (BPD). Two familyโbased association studies showed that the Val allele of the functional polymorphism Val66Met in the __BDNF__ gene is associated with
โฆ LIBER โฆ
Non-replication of the brain-derived neurotrophic factor (BDNF) association in bipolar affective disorder: A Belgian patient-control study
โ Scribed by Oswald, Pierre ;Del-Favero, Jurgen ;Massat, Isabelle ;Souery, Daniel ;Claes, Stephan ;Van Broeckhoven, Christine ;Mendlewicz, Julien
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 50 KB
- Volume
- 129B
- Category
- Article
- ISSN
- 0148-7299
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## Abstract Several lines of evidence indicate an involvement of brain derived neurotrophic factor (BDNF) in body weight regulation and activity: heterozygous __Bdnf__ knockout mice (__Bdnf__^+/โ^) are hyperphagic, obese, and hyperactive; furthermore, central infusion of BDNF leads to severe, doseโ