Non-redundant tumour suppressor functions of transforming growth factor beta in breast cancer
โ Scribed by Mohamad Azhar
- Book ID
- 110644656
- Publisher
- Indian Academy of Sciences
- Year
- 2001
- Tongue
- English
- Weight
- 135 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0250-5991
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Transforming growth factor-โคs (TGFโคs) play a prominent role in tumour growth and metastasis by enhancing angiogenesis and suppressing immune surveillance. Despite the increased interest in the effect of TGFโคs on tumour progression, little is known about the importance of TGFโค3 and its receptor CD105
The transforming growth factors beta are a family of peptides which are involved in the regulation of cell growth and differentiation. It has been suggested that the loss of sensitivity to growth inhibition by endogenous TGF-P may contribute to the process of carcinogenesis in epithelial systems. Ho