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Non-random distribution of mutations in the PHEX gene, and under-detected missense mutations at non-conserved residues

✍ Scribed by Filisetti, Denis; Ostermann, Georg; von Bredow, Moritz; Strom, Tim; Filler, Guido; Ehrich, Johen; Pannetier, Solange; Garnier, Jean-Marie; Rowe, Peter; Francis, Fiona


Book ID
110024843
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
188 KB
Volume
7
Category
Article
ISSN
1018-4813

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The CDKff2 gene, encoding the cyclin-dependent kinase inhibitor p16. is a tumour suppressor gene that maps to chromosome band 9p2 I -p22. The most common mechanism o f inactivation of this gene in human cancers is through homorygous deletion; however, in a smaller proportion of tumours and tumour ce