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Non-peptide fibrinogen receptor antagonists. 21. The synthesis of [3H]L-738,167

โœ Scribed by Terence G. Hamill; Ben C. Askew; George D. Hartman; David A. Claremon; Charles J. McIntyre; H. Donald Burns


Publisher
John Wiley and Sons
Year
1998
Tongue
French
Weight
273 KB
Volume
41
Category
Article
ISSN
0022-2135

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The synthesis of [3H]L-734,217, lb, an orally active fibrinogen receptor antagonist, is described. The conversion of 3-amino crotonate 6 to [3H]L-734,217 was carried out via a two step sequence of catalytic tritiation followed by basic hydrolysis. Deuterium model reactions showed that the reduction

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