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Non-nuclear estrogen receptor β and α in the hippocampus of male and female rats

✍ Scribed by Katarzyna Kalita; Sylwia Szymczak; Leszek Kaczmarek

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
318 KB
Volume
15
Category
Article
ISSN
1050-9631

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✦ Synopsis

Estrogens play important roles in the brain, acting through two receptor types, ER␣ and ER␤, both recognized as transcription factors. In this study, we investigated the ER␤ mRNA and protein expression in the male and female rat brain, focusing on the hippocampus, and comparing with well-known ER␣ expression patterns. Extranuclear ER␤ localization, as shown by light microscopic immunocytochemistry and tissue fractionation experiments, was noted in the hippocampus, whereas nuclear ER␤ was present in the amygdala. Despite these marked differences in subcellular localizations, similar expression levels of ER␤ proteins as well as the profile of ER␤ mRNA isoforms were observed in the two brain structures. ER␣ was localized to the nucleus more so than ER␤, yet not without an extranuclear component. Our results suggest that cytoplasmic estrogen receptors may play an important role in hippocampal physiology.

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